DNA Synthesis Market Size & Share, by Service (Oligonucleotide Synthesis, Gene Synthesis), Method (Solid Phase, PCR-Based), Application (Research & Development, Therapeutic), End-use (Academic & Research Institutes, Biopharmaceutical), Regional Forecast, Industry Players, Growth Statistics Report 2024-2033

Market Outlook:

DNA Synthesis Market size exceeded USD 3.68 Billion in 2023 and is anticipated to cross USD 23.58 Billion by 2033, registering a CAGR of more than 21.45% during the forecast period. The biotechnology and pharmaceutical business sector known as the DNA Synthesis Market focuses on the production of synthetic DNA molecules.

A key step in genetic analysis, molecular biology, biotechnology, and a number of other applications in the biological sciences is DNA synthesis. In order to investigate genes, genetic mutations, and molecular processes, scientists must produce unique DNA sequences, which is where DNA synthesis comes into play. Understanding diseases, creating new drugs, and practising personalised treatment all depend on this. There are several industrial uses for DNA synthesis, including the creation of enzymes, biopolymers, and bio-based compounds. Forensic investigations require DNA synthesis in order to do DNA profiling and identification.

• Base Year Value (2023): USD 3.68 Billion
• CAGR (2024-2033): 21.45%
• Forecast Year Value (2033): USD 23.58 Billion
• Historical Data Period: 2019-2022
• Largest Region: North America
• Forecast Period: 2024-2033

Market Dynamics:

Growth Drivers and Opportunities:

Increasing prevalence of diseases across the world

Food antioxidants are chemicals that can help shield cells from oxidative stress-related cell damage and are present in a variety of foods. They function by scavenging dangerous chemicals known as free radicals. Fruits, vegetables, nuts, and some drinks, such as tea and red wine, all contain antioxidants. Beta-carotene, flavonoids, and the vitamins C and E are some examples of antioxidants. There is an increase in demand for foods and supplements high in antioxidants as people become more health-conscious and aware of the importance of antioxidants in avoiding diseases and preserving general health.

Technological advancement in synthetic biology

Significant progress has been made in the synthetic biology field in recent years. These developments include improvements in DNA sequencing, CRISPR-Cas9 gene editing technology, and numerous instruments and processes for designing and synthesising DNA molecules. With the development of novel applications in industries including synthetic biology, agriculture, and biomanufacturing, as well as the rising demand for personalised DNA sequences, the DNA synthesis market is expected to continue growing as technology develops.

Report Scope

Report Coverage	Details
Segments Covered	Services, Method, Application, End-Use
Regions Covered	• North America (United States, Canada, Mexico)   • Europe (Germany, United Kingdom, France, Italy, Spain, Rest of Europe)   Asia Pacific (China, Japan, South Korea, Singapore, India, Australia, Rest of APAC)   • Latin America (Argentina, Brazil, Rest of South America)   • Middle East & Africa (GCC, South Africa, Rest of MEA)
Company Profiled	Thermo Fisher Scientific, Inc., Twist Bioscience, Bioneer Corporation, Eton Bioscience, LGC Biosearch Technologie, IBA GmbH, Eurofins Scientific, Integrated DNA Technologies, Inc., Quintara Biosciences, GenScript Biotech Corporation

 

Industry Restraints & Challenges

Strict rules made by the government to hamper the market

To prevent the unauthorised synthesis of DNA sequences that could be exploited for harmful reasons, such bioterrorism, governments may enact strict rules. Providers of DNA synthesis may be required by these regulations to check orders, report suspect requests, and put safety precautions in place to defend against misuse. To stop the spread of potentially harmful genetic elements, certain nations may implement export restrictions on DNA synthesis equipment and technologies. Export restrictions may have an impact on the trade of goods used in DNA synthesis.

Regional Forecast:

North American Market

North America region's DNA synthesis market held a 40% revenue share in 2023. The DNA synthesis market was largely concentrated in North America, primarily the United States and Canada. Synthetic biology developments, genomics research, and applications in a variety of sectors, including healthcare, agriculture, and biotechnology, have all contributed to the market's steady expansion. Numerous academic and research institutes in North America are actively involved in genetic research. These organisations frequently need unique DNA sequences for their research, which helps the industry expand.

Asia Pacific Market

Asia Pacific is witnessing the fastest market growth between 2024 to 2033. The DNA synthesis market was expanding quickly in the Asia-Pacific region, which comprises nations like China, India, Japan, South Korea, and others. This expansion was linked to rising financial support for healthcare, biotechnology, and life sciences research in the area. Due to the development of their biotechnology and pharmaceutical industries, as well as a growing emphasis on scientific research and innovation, nations like China and India were emerging as major participants in the DNA synthesis market. These developing nations provided a sizable and risingly skilled labour force.

Segmentation Analysis:

Insights by Service

The Oligonucleotide Synthesis segment accounted the largest market share over around 54% in 2023. Small interfering RNAs (siRNAs) and antisense oligonucleotides are two types of nucleic acid-based therapies that are created using oligonucleotides. The segment is expanding as these therapeutic approaches are being studied for the treatment of cancer, genetic disorders, and other diseases. Oligonucleotides are crucial elements in PCR (polymerase chain reaction) and DNA sequencing, two molecular diagnostic procedures. The market for oligonucleotides is driven by the rising demand for molecular diagnostics, notably in areas like infectious disease testing and personalised medicine.

Insights by Method

The solid phase synthesis segment dominated the market with over 38% share in 2023. The effectiveness and precision of DNA sequence synthesis have been increased by developments in solid-phase synthesis methods and tools. The capabilities of solid-phase synthesis have been increased by advancements in automation, reagent chemistry, and resin materials. Solid-phase synthesis is rising globally as biotechnology and life science research and development activities rise in emerging countries, not just in industrialised markets.

Insights by Application

The research and development segment accounted over 48% of the market share in 2023. For the purpose of finding and creating novel medicines, the pharmaceutical industry invests heavily in R&D. Target identification, validation, and high-throughput screening tests all use custom DNA sequences to quicken the drug discovery process. DNA synthesis is a key tool in synthetic biology for building artificial DNA structures, gene circuits, and biological systems. Synthetic biology research and development helps this industry expand. Genetic data is used in the developing field of personalised medicine to customise medical care for specific individuals. DNA synthesis is in demand because research and development in this field frequently uses DNA sequencing and analysis.

Insights by End Use

The academic and research institutes segment is expected to surpass USD 12.65 billion by 2033. In synthetic biology, where scientists create and build biological systems, circuits, and creatures, academic and research institutions are actively involved. A key technique in this area is custom DNA synthesis. Synthesised DNA constructions and templates are frequently used in the study of gene expression, protein-DNA interactions, and molecular pathways in molecular biology. Academic institutions offer instruction and training in genetics and molecular biology, exposing students to the significance of DNA synthesis in biotechnology and research.

Competitive Landscape:

Major players in the market

• Thermo Fisher Scientific, Inc.
• Twist Bioscience
• Bioneer Corporation
• Eton Bioscience
• LGC Biosearch Technologie
• IBA GmbH
• Eurofins Scientific
• Integrated DNA Technologies, Inc.
• Quintara Biosciences
• GenScript Biotech Corporation